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HarvardScience is a publication of the Harvard Office of News and Public Affairs devoted to all matters related to science at the various schools, departments, institutes, and hospitals of Harvard University.
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Clockwise from left, David Reich, Philip De Jager, and Arti Tandon worked on the study.

(Photo by HMS Public Affairs)

Genome scanning technique spots disease risk

August 25, 2005

A new technique, admixture mapping, takes advantage of the higher-risk genetic segments from one population that show up in the other through generations of racial mixing. The presence of higher-risk segments in the otherwise lower-risk DNA makes for more efficient sorting of the genome to zero in on disease genes. The study, led by David Reich, linked MS for the first time with a region on chromosome 1. Since no gene has yet been pinpointed, the researchers are treating their results as promising evidence that the method may be a valuable additional tool to identify new pathways important in disease.

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