Researchers develop ALS mouse stem cell line

A team of Harvard researchers has used embryonic stem cells, derived from mice carrying a human gene known to cause a form of amyotrophic lateral sclerosis (ALS), to create an in vitro model of the always-fatal neurodegenerative disease. Harvard Stem Cell Institute principal investigator Kevin Eggan and Tom Maniatis, the Thomas H. Lee Professor of Molecular and Cellular Biology in Harvard's Faculty of Arts and Sciences, are the senior authors of the study published on-line April 15 by Nature Neuroscience.