Hormone-induced chromatin looping. Androgen receptor (AR) binding to enhancer and promoter domains of the gene for prostate specific antigen triggers the bending of DNA, assembly of cofactors (unmarked ovals), and tracking of RNA polymerase
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Studies chip away at sex hormone roles in prostate and breast cancersJune 10, 2005In recent work, Myles Brown and colleagues combined chromatin immunoprecipitation (ChiP) assays with measures of DNA structure and large-scale gene chip analyses to study where, when, and how androgen and estrogen receptors attach to DNA and control gene transcription. Their results should lead to new ways of manipulating receptor activity and shutting down cancer genes while leaving normal genes intact. |
