A study, led by McLean Hospital's William Carlezon and Susan Andersen, found that adult rats given Ritalin as juveniles behaved differently than their placebo-treated counterparts in a host of tests that reflect mood and attention. Published in the Dec. 15, 2003 issue of Biological Psychiatry, the study follows up previous work by the researchers showing that young rats given Ritalin were less likely to find cocaine pleasurable as adults.