HIV is a crafty virus. It attacks the body by invading and taking over the very cells meant to protect humans from infection. Hiding within cells such as macrophages and lymphocytes, the virus uses the body's natural machinery to replicate itself, destroying the immune system and leaving patients open to a range of debilitating and deadly opportunistic infections.
Now, a team led by Harvard School of Public Health (HSPH) researchers has described a previously unappreciated pathway used by HIV to enter macrophages and has shown that the virus, once in the cells through this entryway, doesn't appear to replicate. Rather than causing infection, the virus is destroyed, and an immune response may be triggered.
