http://harvardscience.harvard.edu/stories/person/1113 Stories and external links referencing a person (RSS) en http://harvardscience.harvard.edu/medicine-health/articles/sickle-cell-disease-cured-mouse-model <!--paging_filter--><p>Sickle cell disease is a blood disorder caused by a single mutation in the beta-globin gene that results in the substitution of one amino acid. This small error is enough to change the properties of the protein: when "sickled," the blood's hemoglobin dumps its oxygen in tissues, and it tends to stick to itself. This makes red blood cells abnormally rigid, adhesive, and distorted into the hallmark sickle shapes that characterize the disease. Now, Harvard Medical School researchers have used a gene therapy to cure sickle cell disease in a mouse model. The achievement, announced in the Dec.</p> <p><a href="http://harvardscience.harvard.edu/medicine-health/articles/sickle-cell-disease-cured-mouse-model">read more</a></p> Mon, 26 Mar 2007 05:17:54 -0400 70652986 3089 at http://harvardscience.harvard.edu