http://harvardscience.harvard.edu/stories/person/911 Stories and external links referencing a person (RSS) en http://harvardscience.harvard.edu/medicine-health/articles/cancer-link-protein-promiscuity-being-studied <!--paging_filter--><p>When found at abnormally high concentrations, two proteins implicated in many human cancers have the potential to spur indiscriminate biochemical signaling inside cells, chemists at Harvard University have found. Their finding may expand scientists' current understanding of oncogenesis - that cancer arises when an oncoprotein becomes overactive, ramping up the biochemical pathways that it normally activates - suggesting that an important additional mechanism could be the inappropriate activation of numerous secondary pathways.</p> <p><a href="http://harvardscience.harvard.edu/medicine-health/articles/cancer-link-protein-promiscuity-being-studied">read more</a></p> Fri, 20 Jul 2007 09:49:13 -0400 50443248 4488 at http://harvardscience.harvard.edu http://harvardscience.harvard.edu/medicine-health/articles/identifying-source-all-disease <!--paging_filter--><p>In a major leap toward learning the basics of human biology and what makes it go awry, Harvard researchers have built the prototype of a high-tech chip that rapidly identifies proteins and their functions. Such chips may ultimately help to determine which proteins are responsible for which diseases. "We don't yet know how many different proteins make up a human body," admits Gavin MacBeath of Harvard University's Center for Genomic Research. "We think it's somewhere between 25,000 and 120,000. It may not be possible to make every one in a laboratory, but I believe that many of them can be made. Then they could be put on small glass chips that would allow us to determine what proteins potential drugs would bind to, or help us search for new drugs more efficiently."</p> Mon, 26 Mar 2007 05:04:03 -0400 70652986 2749 at http://harvardscience.harvard.edu